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Checkpoint inhibition of PD-L1 and CTLA-4 in a child with refractory acute leukemia
Children with multiple relapsed or refractory leukemia have dismal survival. Research has identified engagement of immune checkpoint receptors (e.g., PD-1, PD-L1 and CTLA-4) as a mechanism for treatment resistance. For adult cancer, inhibitors of PD-1 (nivolumab) and CTLA-4 (ipilimumab) have shown p...
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| Publicado no: | Int J Hematol Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Future Medicine Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6410023/ https://ncbi.nlm.nih.gov/pubmed/30863527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/ijh-2018-0009 |
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