iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds

There is a profound need for functional, biomimetic in vitro tissue constructs of the human blood-brain barrier and neurovascular unit (NVU) to model diseases and identify therapeutic interventions. Here, we show that induced pluripotent stem cell (iPSC)-derived human brain microvascular endothelial...

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Gepubliceerd in:Stem Cell Reports
Hoofdauteurs: Faley, Shannon L., Neal, Emma H., Wang, Jason X., Bosworth, Allison M., Weber, Callie M., Balotin, Kylie M., Lippmann, Ethan S., Bellan, Leon M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409430/
https://ncbi.nlm.nih.gov/pubmed/30773484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.01.009
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