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A recombinant human protein targeting HER2 overcomes drug resistance in HER2-positive breast cancer
Resistance to current HER2 inhibitors, such as trastuzumab (Ttzm), is a major unresolved clinical problem in HER2-positive BC (HER2-BC). Because HER2 remains overexpressed in drug-resistant HER2-BC cells, we investigated whether PEPD(G278D) can overcome the resistance. PEPD(G278D) is a recombinant e...
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| Publicado no: | Sci Transl Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6409101/ https://ncbi.nlm.nih.gov/pubmed/30674653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav1620 |
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