A rare missense variant in CASP7 is associated with familial late-onset Alzheimer disease

INTRODUCTION: The genetic architecture of Alzheimer disease (AD) is only partially understood. METHODS: We conducted an association study for AD using whole sequence data from 507 genetically enriched AD cases (i.e., cases having close relatives affected by AD) and 4,917 cognitively healthy controls...

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Détails bibliographiques
Publié dans:Alzheimers Dement
Auteurs principaux: Zhang, Xiaoling, Zhu, Congcong, Beecham, Gary, Vardarajan, Badri N., Ma, Yiyi, Lancour, Daniel, Farrell, John J., Chung, Jaeyoon, Mayeux, Richard, Haines, Jonathan L., Schellenberg, Gerard D., Pericak-Vance, Margaret A., Lunetta, Kathryn L, Farrer, Lindsay A.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408965/
https://ncbi.nlm.nih.gov/pubmed/30503768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2018.10.005
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