Fusion proteins consisting of Bet v 1 and Phl p 5 form IgE-reactive aggregates with reduced allergenic activity

The cross-linking of effector cell-bound IgE antibodies by allergens induces the release of inflammatory mediators which are responsible for the symptoms of allergy. We demonstrate that a recombinant hybrid molecule consisting of the major birch (Bet v 1) and grass (Phl p 5) pollen allergen exhibite...

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Udgivet i:Sci Rep
Main Authors: Najafi, N., Hofer, G., Gattinger, P., Smiljkovic, D., Blatt, K., Selb, R., Stoecklinger, A., Keller, W., Valent, P., Niederberger, V., Thalhamer, J., Valenta, R., Flicker, S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408504/
https://ncbi.nlm.nih.gov/pubmed/30850635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39798-8
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