Flexible IgE epitope containing domains of Phl p 5 cause high allergenic activity

This is the first study determining the three-dimensional structure of Phl p 5a which reveals a novel mechanism for high allergenic activity based on flexibly connected IgE-reactive domains which cross-link effector cell-bound IgE more efficiently than isolated rigid globular proteins. These finding...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Göbl, Christoph, Focke-Tejkl, Margarete, Najafi, Nazanin, Schrank, Evelyne, Madl, Tobias, Kosol, Simone, Madritsch, Christoph, Dorofeeva, Yulia, Flicker, Sabine, Thalhamer, Josef, Valenta, Rudolf, Zangger, Klaus, Tjandra, Nico
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632575/
https://ncbi.nlm.nih.gov/pubmed/28532654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.05.005
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