Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers

The liver plays a central role in metabolism; however, xenobiotic metabolism variations between human hepatocytes and those in model organisms create challenges in establishing functional test beds to detect the potential drug toxicity and efficacy of candidate small molecules. In the emerging areas...

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Vydáno v:Cell Metab
Hlavní autoři: Mancio-Silva, Liliana, Fleming, Heather E., Miller, Alex B., Milstein, Stuart, Liebow, Abigail, Haslett, Patrick, Sepp-Lorenzino, Laura, Bhatia, Sangeeta N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408324/
https://ncbi.nlm.nih.gov/pubmed/30840913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.02.003
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