PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response

The G2/M checkpoint inhibits mitotic entry upon DNA damage thereby preventing segregation of broken chromosomes and preserving genome stability. The tumor suppressor proteins BRCA1, PALB2 and BRCA2 constitute a BRCA1-PALB2-BRCA2 axis that is essential for homologous recombination (HR)-based DNA doub...

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Bibliografiska uppgifter
I publikationen:Oncogene
Huvudupphovsmän: Simhadri, Srilatha, Vincelli, Gabriele, Huo, Yanying, Misenko, Sarah, Foo, Tzeh Keong, Ahlskog, Johanna, Sorensen, Claus S, Oakley, Gregory G, Ganesan, Shridar, Bunting, Samuel F, Xia, Bing
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408219/
https://ncbi.nlm.nih.gov/pubmed/30337689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0535-2
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