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The (still) underappreciated role of allostery in the cellular network

Allosteric propagation results in communication between distinct sites in the protein structure; it also encodes specific effects on cellular pathways, and in this way it shapes cellular response. One example of long-range effects is binding of morphogens to cell-surface receptors, which initiates a...

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Bibliografiska uppgifter
I publikationen:Annu Rev Biophys
Huvudupphovsmän: Nussinov, Ruth, Tsai, Chung-Jung, Ma, Buyong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407633/
https://ncbi.nlm.nih.gov/pubmed/23451894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biophys-083012-130257
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