C679X loss-of-function PCSK9 variant is associated with lower fasting glucose in black South African adolescents: Birth to Twenty Plus Cohort

AIM: To evaluate the association between loss-of-function (LOF) PCSK9 variants (A433T/rs28362263 and C679X/rs28362286) and biomarkers of cardiometabolic risk, specifically fasting glucose and low density lipoprotein cholesterol (LDL-C) concentrations. METHODS: Our study comprised 757 male and female...

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Detalhes bibliográficos
Publicado no:J Clin Transl Endocrinol
Main Authors: Chikowore, Tinashe, Sahibdeen, Venesa, Hendry, Liesl M., Norris, Shane A., Goedecke, Julia H., Micklesfield, Lisa K., Lombard, Zané
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407309/
https://ncbi.nlm.nih.gov/pubmed/30899674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcte.2019.100186
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