Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress

BACKGROUND: Angiotensin II (ANGII) and its receptor (AGTR1) have been proposed as significant contributors to metastasis in multiple cancers. Further, high AGTR1 levels are associated with poor epithelial ovarian cancer (EOC) outcomes. However, the mechanistic basis for these effects is unknown. Rec...

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Bibliografski detalji
Izdano u:J Exp Clin Cancer Res
Glavni autori: Zhang, Qingyu, Yu, Shan, Lam, Melody Man Ting, Poon, Terence Chuen Wai, Sun, Litao, Jiao, Yufei, Wong, Alice Sze Tsai, Lee, Leo Tsz On
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407256/
https://ncbi.nlm.nih.gov/pubmed/30845964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1127-x
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