In Silico Study Probes Potential Inhibitors of Human Dihydrofolate Reductase for Cancer Therapeutics

Dihydrofolate reductase (DHFR) is an essential cellular enzyme and thereby catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). In cancer medication, inhibition of human DHFR (hDHFR) remains a promising strategy, as it depletes THF and slows DNA synthesis and cell proliferation. In th...

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Detalhes bibliográficos
Publicado no:J Clin Med
Main Authors: Rana, Rabia Mukhtar, Rampogu, Shailima, Zeb, Amir, Son, Minky, Park, Chanin, Lee, Gihwan, Yoon, Sanghwa, Baek, Ayoung, Parameswaran, Sarvanan, Park, Seok Ju, Lee, Keun Woo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406960/
https://ncbi.nlm.nih.gov/pubmed/30754680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm8020233
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