Diastereomeric Recognition of 5’,8-cyclo-2’-Deoxyadenosine Lesions by Human Poly(ADP-ribose) Polymerase 1 in a Biomimetic Model

5’,8-Cyclo-2’-deoxyadenosine (cdA), in the 5’R and 5’Sdiastereomeric forms, are typical non strand-break oxidative DNA lesions, induced by hydroxyl radicals, with emerging importance as a molecular marker. These lesions are exclusively repaired by the nucleotide excision repair (NER) mechanism with...

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Publicado no:Cells
Main Authors: Masi, Annalisa, Sabbia, Arianna, Ferreri, Carla, Manoli, Francesco, Lai, Yanhao, Laverde, Eduardo, Liu, Yuan, Krokidis, Marios G., Chatgilialoglu, Chryssostomos, Faraone Mennella, Maria Rosaria
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406461/
https://ncbi.nlm.nih.gov/pubmed/30717407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8020116
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