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The epigenetic basis for the impaired ability of adult murine retinal pigment epithelium cells to regenerate retinal tissue

The epigenetic plasticity of amphibian retinal pigment epithelium (RPE) allows them to regenerate the entire retina, a trait known to be absent in mammals. In this study, we investigated the epigenetic plasticity of adult murine RPE to identify possible mechanisms that prevent mammalian RPE from reg...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Dvoriantchikova, Galina, Seemungal, Rajeev J., Ivanov, Dmitry
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405859/
https://ncbi.nlm.nih.gov/pubmed/30846751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40262-w
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