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Identification of a novel scaffold for a small molecule GPR139 receptor agonist
GPR139 is an orphan G protein-coupled receptor (GPCR) that is primarily expressed in the brain in regions known to regulate motor control and metabolism. Here, we screened a diverse 4,000 compound library in order to identify GPR139 agonists. We identified 11 initial hits in a calcium mobilization s...
Enregistré dans:
| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6405842/ https://ncbi.nlm.nih.gov/pubmed/30846711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40085-9 |
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