Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate Lithogenesis

BACKGROUND: In the kidney, low urinary citrate increases the risk for developing kidney stones, and elevation of luminal succinate in the juxtaglomerular apparatus increases renin secretion, causing hypertension. Although the association between stone formation and hypertension is well established,...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Khamaysi, Ahlam, Anbtawee-Jomaa, Shireen, Fremder, Moran, Eini-Rider, Hadar, Shimshilashvili, Liana, Aharon, Sara, Aizenshtein, Elina, Shlomi, Tomer, Noguchi, Audrey, Springer, Danielle, Moe, Orson W., Shcheynikov, Nikolay, Muallem, Shmuel, Ohana, Ehud
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2019
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405146/
https://ncbi.nlm.nih.gov/pubmed/30728179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018030277
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