Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice

Our previous study showed that miR-29 attenuates muscle wasting in chronic kidney disease. Other studies found that miR-29 has anti-fibrosis activity. We hypothesized that intramuscular injection of exosome-encapsulated miR-29 would counteract unilateral ureteral obstruction (UUO)-induced muscle was...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Wang, Haidong, Wang, Bin, Zhang, Aiqing, Hassounah, Faten, Seow, Yiqi, Wood, Matthew, Ma, Fuying, Klein, Janet D., Price, S. Russ, Wang, Xiaonan H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403486/
https://ncbi.nlm.nih.gov/pubmed/30711446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.01.008
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