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Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity
AAV vectors poorly transduce Dendritic cells (DC), a feature invoked to explain AAV’s low immunogenicity. However, the reason for this non-permissiveness remained elusive. Here, we performed an in-depth analysis using human monocyte-derived immature DC (iDC) as model. iDC internalized AAV vectors of...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6403382/ https://ncbi.nlm.nih.gov/pubmed/30842485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40071-1 |
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