Notch Signaling Mediates Astrocyte Abnormality in Spinal Muscular Atrophy Model Systems

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by the degeneration of spinal motor neurons and muscle atrophy. The disease is mainly caused by low level of the survival motor neuron (SMN) protein, which is coded by two genes, namely SMN1 and SMN2, but le...

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Publicat a:Sci Rep
Autors principals: Ohuchi, Kazuki, Funato, Michinori, Yoshino, Yuta, Ando, Shiori, Inagaki, Satoshi, Sato, Arisu, Kawase, Chizuru, Seki, Junko, Saito, Toshio, Nishio, Hisahide, Nakamura, Shinsuke, Shimazawa, Masamitsu, Kaneko, Hideo, Hara, Hideaki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403369/
https://ncbi.nlm.nih.gov/pubmed/30842449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39788-w
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