Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide

Microbial resistance against clinical used antibiotics is on the rise. Accordingly, there is a high demand for new innovative antimicrobial strategies. The host-defense peptide human beta-defensin 1 (hBD-1) is produced continuously by epithelial cells and exhibits compelling antimicrobial activity a...

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Vydáno v:Sci Rep
Hlavní autoři: Wendler, Judith, Schroeder, Bjoern O., Ehmann, Dirk, Koeninger, Louis, Mailänder-Sánchez, Daniela, Lemberg, Christina, Wanner, Stephanie, Schaller, Martin, Stange, Eduard F., Malek, Nisar P., Weidenmaier, Christopher, LeibundGut-Landmann, Salomé, Wehkamp, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403363/
https://ncbi.nlm.nih.gov/pubmed/30842543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40216-2
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