Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is a rising cause of hepatocellular carcinoma (HCC). We examined whether inherited pathogenic variants in candidate genes (n = 181) were enriched in patients with NAFLD-HCC. To this end, we resequenced peripheral blood DNA of 142 NAFLD-HCC, 59 NAFLD with adva...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Pelusi, Serena, Baselli, Guido, Pietrelli, Alessandro, Dongiovanni, Paola, Donati, Benedetta, McCain, Misti Vanette, Meroni, Marica, Fracanzani, Anna Ludovica, Romagnoli, Renato, Petta, Salvatore, Grieco, Antonio, Miele, Luca, Soardo, Giorgio, Bugianesi, Elisabetta, Fargion, Silvia, Aghemo, Alessio, D’Ambrosio, Roberta, Xing, Chao, Romeo, Stefano, De Francesco, Raffaele, Reeves, Helen Louise, Valenti, Luca Vittorio Carlo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403344/
https://ncbi.nlm.nih.gov/pubmed/30842500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39998-2
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