A Randomized, Proof-of-Concept Clinical Trial on Repurposing Chlorcyclizine for the Treatment of Chronic Hepatitis C

BACKGROUND & AIMS: Chlorcyclizine HCl (CCZ) is a piperazine-class antihistamine with anti-hepatitis C virus (HCV) activity in vitro and in vivo. In a first-in-humans study for HCV, we evaluated the antiviral effects and safety of CCZ±ribavirin (RBV), characterized pharmacokinetic (PK) and viral...

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書誌詳細
出版年:Antiviral Res
主要な著者: Koh, Christopher, Dubey, Preeti, Han, Ma Ai Thanda, Walter, Peter J., Garraffo, H. Martin, Surana, Pallavi, Southall, Noel T., Borochov, Nathaniel, Uprichard, Susan L., Cotler, Scott J, Etzion, Ohad, Heller, Theo, Dahari, Harel, Liang, T. Jake
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402797/
https://ncbi.nlm.nih.gov/pubmed/30711416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2019.01.017
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