Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion

Cyclic nucleotide signalling is a major regulator of malaria parasite differentiation. Phosphodiesterase (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the parasite, but the mechanisms by which cyclic AMP (cAMP) is regulated remain enigmatic. Here, we demonstrate that Plasmodium falc...

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Udgivet i:PLoS Biol
Main Authors: Flueck, Christian, Drought, Laura G., Jones, Andrew, Patel, Avnish, Perrin, Abigail J., Walker, Eloise M., Nofal, Stephanie D., Snijders, Ambrosius P., Blackman, Michael J., Baker, David A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402698/
https://ncbi.nlm.nih.gov/pubmed/30794532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000154
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