Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities

Sirtuin inhibitors have attracted much interest due to the involvement of sirtuins in various biological processes. Several SIRT2-selective inhibitors have been developed, and some exhibit anticancer activities. To facilitate the choice of inhibitors in future studies and the development of better i...

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Pubblicato in:ChemMedChem
Autori principali: Spiegelman, Nicole A., Price, Ian R., Jing, Hui, Wang, Miao, Yang, Min, Cao, Ji, Hong, Jun Young, Zhang, Xiaoyu, Aramsangtienchai, Pornpun, Sadhukhan, Sushabhan, Lin, Hening
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402572/
https://ncbi.nlm.nih.gov/pubmed/30058233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800391
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