The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality

Tight control of energy metabolism is essential for normal cell function and organism survival. PKM (pyruvate kinase, muscle) isoforms 1 and 2 originate from alternative splicing of PKM pre-mRNA. They are key enzymes in oxidative phosphorylation and aerobic glycolysis, respectively, and are essentia...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Li, Yan-Ru, Peng, Rui-Rui, Gao, Wen-Yi, Liu, Peng, Chen, Liang-Jian, Zhang, Xiao-Lan, Zhang, Na-Na, Wang, Yang, Du, Lei, Zhu, Feng-Yu, Wang, Li-Li, Li, Cong-Rong, Zeng, Wen-Tao, Li, Jian-Min, Hu, Fan, Zhang, Dong, Yang, Zhi-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402520/
https://ncbi.nlm.nih.gov/pubmed/30786262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101802
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