Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor

The poly(ADP-ribose) polymerase (PARP) family of enzymes plays a crucial role in cellular and molecular processes including DNA damage detection and repair, and transcription; indeed, PARP inhibitors are under clinical evaluation as chemotherapeutic adjuncts given their capacity to impede genomic DN...

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Udgivet i:ACS Chem Biol
Main Authors: Krainz, Tanja, Lamade, Andrew M., Du, Lina, Maskrey, Taber S., Calderon, Michael, Watkins, Simon C., Epperly, Michael W., Greenberger, Joel S., Bayır, Hülya, Wipf, Peter, Clark, Robert S. B.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402482/
https://ncbi.nlm.nih.gov/pubmed/30184433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00423
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