Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromatic N-oxide a structural alert for predicting DNA-reactive mutagenicity?()

(Quantitative) structure–activity relationship or (Q)SAR predictions of DNA-reactive mutagenicity are important to support both the design of new chemicals and the assessment of impurities, degradants, metabolites, extractables and leachables, as well as existing chemicals. Aromatic N-oxides represe...

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Publicado en:Mutagenesis
Main Authors: Amberg, Alexander, Anger, Lennart T, Bercu, Joel, Bower, David, Cross, Kevin P, Custer, Laura, Harvey, James S, Hasselgren, Catrin, Honma, Masamitsu, Johnson, Candice, Jolly, Robert, Kenyon, Michelle O, Kruhlak, Naomi L, Leavitt, Penny, Quigley, Donald P, Miller, Scott, Snodin, David, Stavitskaya, Lidiya, Teasdale, Andrew, Trejo-Martin, Alejandra, White, Angela T, Wichard, Joerg, Myatt, Glenn J
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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Original Manuscripts
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402318/
https://ncbi.nlm.nih.gov/pubmed/30189015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gey020
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