Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

BACKGROUND: RING finger protein 38 (RNF38), a member of the RNF protein family, has just emerged as a vital driver of cancer progression. However, the oncogenic mechanisms of RNF38 remain unexplored. METHODS: Using frozen tumor tissue and tissue microarray from hepatocellular carcinoma (HCC) patient...

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Gepubliceerd in:J Exp Clin Cancer Res
Hoofdauteurs: Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Wei, Chuan-Yuan, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Bai, Dou-Sheng, Shi, Guo-Ming, Ke, Ai-Wu, Fan, Jia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402116/
https://ncbi.nlm.nih.gov/pubmed/30836988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1113-3
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