Allopregnanolone treatment improves plasma metabolomic profile associated with GABA metabolism in Fragile X-associated Tremor/Ataxia Syndrome: a pilot study

Currently there is no effective treatment for the Fragile X-associated Tremor/Ataxia Syndrome (FXTAS), a late-onset neurodegenerative disorder. In this pilot study, we evaluated whether allopregnanolone, a natural neurosteroid that exerts beneficial effects in neurodegenerative diseases, nervous sys...

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Publicado en:Mol Neurobiol
Main Authors: Napoli, Eleonora, Schneider, Andrea, Wang, Jun Yi, Trivedi, Aditi, Carrillo, Nika Roa, Tassone, Flora, Rogawski, Michael, Hagerman, Randi J., Giulivi, Cecilia
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401336/
https://ncbi.nlm.nih.gov/pubmed/30187385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1330-3
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