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Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2

The fibroblast growth factor receptor 2 (FGFR2) is a membrane receptor that promotes cell proliferation and differentiation. FGFR2 is also present in the nucleus, which raises a question on a new role of FGFR2 in regulating gene expression. Hypoxia-inducible factors 1 and 2 (HIF-1 and HIF-2) are nuc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lee, Jae Eun, Shin, Seung-Hyun, Shin, Hyun-Woo, Chun, Yang-Sook, Park, Jong-Wan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401139/
https://ncbi.nlm.nih.gov/pubmed/30837551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39843-6
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