Bone-Specific Overexpression of PITX1 Induces Senile Osteoporosis in Mice Through Deficient Self-Renewal of Mesenchymal Progenitors and Wnt Pathway Inhibition

The cellular and molecular mechanisms underlying senile osteoporosis remain poorly understood. In this study, transgenic mCol1α1-Pitx1 mice overexpressing paired-like homeodomain 1 (PITX1), a homeobox transcription factor, rapidly develop a severe type-II osteoporotic phenotype with significant redu...

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Published in:Sci Rep
Main Authors: Karam, Nancy, Lavoie, Jean-François, St-Jacques, Benoit, Bouhanik, Saadallah, Franco, Anita, Ladoul, Nihad, Moreau, Alain
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401072/
https://ncbi.nlm.nih.gov/pubmed/30837642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40274-6
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