A high-avidity biosensor reveals plasma membrane PI(3,4)P(2) is predominantly a class I PI3K signaling product

Class I phosphoinositide 3-OH kinase (PI3K) signaling is central to animal growth and metabolism, and pathological disruption of this pathway affects cancer and diabetes. However, the specific spatial/temporal dynamics and signaling roles of its minor lipid messenger, phosphatidylinositol (3,4)-bisp...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Goulden, Brady D., Pacheco, Jonathan, Dull, Allyson, Zewe, James P., Deiters, Alexander, Hammond, Gerald R.V.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400549/
https://ncbi.nlm.nih.gov/pubmed/30591513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201809026
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