EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

The fibronectin EDA isoform (EDA FN) is instrumental in fibrogenesis but, to date, its expression and function in bone marrow (BM) fibrosis have not been explored. We found that mice constitutively expressing the EDA domain (EIIIA(+/+)), but not EDA knockout mice, are more prone to develop BM fibros...

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Publicado en:J Exp Med
Main Authors: Malara, Alessandro, Gruppi, Cristian, Abbonante, Vittorio, Cattaneo, Daniele, De Marco, Luigi, Massa, Margherita, Iurlo, Alessandra, Gianelli, Umberto, Balduini, Carlo L., Tira, Maria E., Muro, Andrès F., Chauhan, Anil K., Rosti, Vittorio, Barosi, Giovanni, Balduini, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400533/
https://ncbi.nlm.nih.gov/pubmed/30733282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181074
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