EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

The fibronectin EDA isoform (EDA FN) is instrumental in fibrogenesis but, to date, its expression and function in bone marrow (BM) fibrosis have not been explored. We found that mice constitutively expressing the EDA domain (EIIIA(+/+)), but not EDA knockout mice, are more prone to develop BM fibros...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Exp Med
Päätekijät: Malara, Alessandro, Gruppi, Cristian, Abbonante, Vittorio, Cattaneo, Daniele, De Marco, Luigi, Massa, Margherita, Iurlo, Alessandra, Gianelli, Umberto, Balduini, Carlo L., Tira, Maria E., Muro, Andrès F., Chauhan, Anil K., Rosti, Vittorio, Barosi, Giovanni, Balduini, Alessandra
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Rockefeller University Press 2019
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Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400533/
https://ncbi.nlm.nih.gov/pubmed/30733282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181074
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