The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening

A group of human mutations within the N-terminal (NT) domain of connexin 26 (Cx26) hemichannels produce aberrant channel activity, which gives rise to deafness and skin disorders, including keratitis-ichthyosis-deafness (KID) syndrome. Structural and functional studies indicate that the NT of connex...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Gen Physiol
Egile Nagusiak: Valdez Capuccino, Juan M., Chatterjee, Payal, García, Isaac E., Botello-Smith, Wesley M., Zhang, Han, Harris, Andrew L., Luo, Yun, Contreras, Jorge E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2019
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400520/
https://ncbi.nlm.nih.gov/pubmed/30530766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812219
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