Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm

Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca(2+))-activated nonselective cationic current (I(CAN)) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing I(CAN) is predicted to slow down or stop breathing; its co...

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Vydáno v:PLoS Biol
Hlavní autoři: Picardo, Maria Cristina D., Sugimura, Yae K., Dorst, Kaitlyn E., Kallurkar, Prajkta S., Akins, Victoria T., Ma, Xingru, Teruyama, Ryoichi, Guinamard, Romain, Kam, Kaiwen, Saha, Margaret S., Del Negro, Christopher A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400419/
https://ncbi.nlm.nih.gov/pubmed/30789900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006094
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