Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm

Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca(2+))-activated nonselective cationic current (I(CAN)) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing I(CAN) is predicted to slow down or stop breathing; its co...

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Publicat a:PLoS Biol
Autors principals: Picardo, Maria Cristina D., Sugimura, Yae K., Dorst, Kaitlyn E., Kallurkar, Prajkta S., Akins, Victoria T., Ma, Xingru, Teruyama, Ryoichi, Guinamard, Romain, Kam, Kaiwen, Saha, Margaret S., Del Negro, Christopher A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400419/
https://ncbi.nlm.nih.gov/pubmed/30789900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006094
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