Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway

The Fanconi Anemia (FA) pathway is a multi-step DNA repair process at stalled replication forks in response to DNA interstrand cross-links (ICLs). Pathological mutation of key FA genes leads to the inherited disorder FA, characterized by progressive bone marrow failure and cancer predisposition. The...

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Vydáno v:PLoS Genet
Hlavní autoři: Wang, Jingming, Chan, Bryan, Tong, Michael, Paung, YiTing, Jo, Ukhyun, Martin, Dwight, Seeliger, Markus, Haley, John, Kim, Hyungjin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400411/
https://ncbi.nlm.nih.gov/pubmed/30789902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007983
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