USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta

USP22, a component of the SAGA complex, is overexpressed in highly aggressive cancers, but the normal functions of this deubiquitinase are not well defined. We determined that loss of USP22 in mice results in embryonic lethality due to defects in extra-embryonic placental tissues and failure to esta...

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Dades bibliogràfiques
Publicat a:Development
Autors principals: Koutelou, Evangelia, Wang, Li, Schibler, Andria C., Chao, Hsueh-Ping, Kuang, Xianghong, Lin, Kevin, Lu, Yue, Shen, Jianjun, Jeter, Collene R., Salinger, Andrew, Wilson, Marenda, Chen, Yi Chun, Atanassov, Boyko S., Tang, Dean G., Dent, Sharon Y. R.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398448/
https://ncbi.nlm.nih.gov/pubmed/30718289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.174037
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