Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling

Celastrol, derived from the roots of the Tripterygium Wilfordi, shows a striking effect on obesity. In the present study, the role of celastrol in cholestasis was investigated using metabolomics and transcriptomics. Celastrol treatment significantly alleviated cholestatic liver injury in mice induce...

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Vydáno v:Mol Cell Proteomics
Hlavní autoři: Zhao, Qi, Liu, Fang, Cheng, Yan, Xiao, Xue-Rong, Hu, Dan-Dan, Tang, Ying-Mei, Bao, Wei-Min, Yang, Jin-Hui, Jiang, Tao, Hu, Jia-Peng, Gonzalez, Frank J., Li, Fei
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398203/
https://ncbi.nlm.nih.gov/pubmed/30617157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000817
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