Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization

The fumarate ester dimethyl fumarate (DMF) has been introduced recently as a treatment for relapsing remitting multiple sclerosis (RRMS), a chronic inflammatory condition that results in neuronal demyelination and axonal loss. DMF is known to act by depleting intracellular glutathione and modifying...

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Vydáno v:Mol Cell Proteomics
Hlavní autoři: Piroli, Gerardo G., Manuel, Allison M., Patel, Tulsi, Walla, Michael D., Shi, Liang, Lanci, Scott A., Wang, Jingtian, Galloway, Ashley, Ortinski, Pavel I., Smith, Deanna S., Frizzell, Norma
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2019
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398201/
https://ncbi.nlm.nih.gov/pubmed/30587509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000922
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