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Bladder cancer extracellular vesicles drive tumorigenesis by inducing the unfolded protein response in endoplasmic reticulum of nonmalignant cells

The field cancerization effect has been proposed to explain bladder cancer's multifocal and recurrent nature, yet the mechanisms of this effect remain unknown. In this work, using cell biology, flow cytometry, and qPCR analyses, along with a xenograft mouse tumor model, we show that chronic exp...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wu, Chia-Hao, Silvers, Christopher R., Messing, Edward M., Lee, Yi-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398136/
https://ncbi.nlm.nih.gov/pubmed/30593508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006682
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