The COX2 effector microsomal PGE2 synthase-1 is a regulator of immunosuppression in cutaneous melanoma

PURPOSE: Microsomal prostaglandin E2 synthase 1 (mPGES1) was evaluated as an important downstream effector of the cyclooxygenase 2 (COX2) pathway responsible for tumor-mediated immunosuppression in melanoma. EXPERIMENTAL DESIGN: The analysis of a Stage III melanoma tissue microarray (n=91) was perfo...

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Published in:Clin Cancer Res
Main Authors: Kim, Sun-Hee, Jason, Roszik, Cho, Sungnam, Ogata, Dai, Milton, Denái R., Peng, Weiyi, Menter, David G., Ekmekcioglu, Suhendan, Grimm, Elizabeth A.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397703/
https://ncbi.nlm.nih.gov/pubmed/30538110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1163
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