GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage

Mammalian glycerophosphodiesterases (GDEs) were recently shown to be involved in multiple cellular signaling pathways. This study showed that decreased GDE5 expression results in accumulation of intracellular glycerophosphocholine (GPC), showing that GDE5 is actively involved in GPC/choline metaboli...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Okazaki, Yuri, Nakamura, Keishi, Takeda, Shuto, Yoshizawa, Ikumi, Yoshida, Fumiyo, Ohshima, Noriyasu, Izumi, Takashi, Klein, Janet D., Kumrungsee, Thanutchaporn, Sands, Jeff M., Yanaka, Noriyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397339/
https://ncbi.nlm.nih.gov/pubmed/30462540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00305.2018
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