MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

Matrix metalloproteinase-9 (MMP-9) has been implicated as being an important pathogenic factor in inflammatory bowel disease (IBD). MMP-9 is markedly elevated in intestinal tissue of patients with IBD, and IBD patients have a defective intestinal tight-junction (TJ) barrier manifested by an increase...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Al-Sadi, Rana, Youssef, Moustafa, Rawat, Manmeet, Guo, Shuhong, Dokladny, Karol, Haque, Mohammad, Watterson, Martin D., Ma, Thomas Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397336/
https://ncbi.nlm.nih.gov/pubmed/30543452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00126.2018
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