Mutational profile of Brazilian lung adenocarcinoma unveils association of EGFR mutations with high Asian ancestry and independent prognostic role of KRAS mutations

Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KR...

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Publicado en:Sci Rep
Autores principales: Leal, Letícia Ferro, de Paula, Flávia Escremim, De Marchi, Pedro, de Souza Viana, Luciano, Pinto, Gustavo Dix Junqueira, Carlos, Carolina Dias, Berardinelli, Gustavo Noriz, Miziara, José Elias, da Silva, Carlos Maciel, Silva, Eduardo Caetano Albino, Pereira, Rui, de Oliveira, Marco Antonio, Scapulatempo-Neto, Cristovam, Reis, Rui Manuel
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397232/
https://ncbi.nlm.nih.gov/pubmed/30824880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39965-x
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