Targeted delivery of TLR3 agonist to tumor cells with single chain antibody fragment-conjugated nanoparticles induces type I-interferon response and apoptosis

Application of Toll-like receptor (TLR) agonists is a promising approach to treat cancer. In particular, nucleic acid-based TLR agonists such as short ssRNA and dsRNA molecules, which activate endosomal TLRs, can be delivered to tumors by use of nanoparticle delivery systems. However, such delivery...

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Опубликовано в: :Sci Rep
Главные авторы: Schau, Isabell, Michen, Susanne, Hagstotz, Alexander, Janke, Andreas, Schackert, Gabriele, Appelhans, Dietmar, Temme, Achim
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397204/
https://ncbi.nlm.nih.gov/pubmed/30824859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40032-8
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