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Deletion of Seventeen Amino Acids at the C-Terminal End of Aquaporin 0 Causes Distortion Aberration and Cataract in the Lenses of AQP0(ΔC/ΔC) Mice
PURPOSE: Investigate the effects of the absence of 17 amino acids at the C-terminal end of Aquaporin 0 (AQP0) on lens transparency, focusing property, and homeostasis. METHODS: A knockin (KI) mouse model (AQP0(ΔC/ΔC)) was developed to express AQP0 only as the end-cleaved form in the lens. For this,...
Enregistré dans:
| Publié dans: | Invest Ophthalmol Vis Sci |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Association for Research in Vision and Ophthalmology
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6397018/ https://ncbi.nlm.nih.gov/pubmed/30821811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.18-26378 |
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