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Abnormal TDP‐43 function impairs activity‐dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing

Aberrant function of the RNA‐binding protein TDP‐43 has been causally linked to multiple neurodegenerative diseases. Due to its large number of targets, the mechanisms through which TDP‐43 malfunction cause disease are unclear. Here, we report that knockdown, aggregation, or disease‐associated mutat...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Tann, Jason Y, Wong, Lik‐Wei, Sajikumar, Sreedharan, Ibáñez, Carlos F
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6396160/
https://ncbi.nlm.nih.gov/pubmed/30692134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100989
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