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Targeting NAD(+) Metabolism as Interventions for Mitochondrial Disease
Leigh syndrome is a mitochondrial disease characterized by neurological disorders, metabolic abnormality and premature death. There is no cure for Leigh syndrome; therefore, new therapeutic targets are urgently needed. In Ndufs4-KO mice, a mouse model of Leigh syndrome, we found that Complex I defic...
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| Publicado no: | Sci Rep |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6395802/ https://ncbi.nlm.nih.gov/pubmed/30816177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39419-4 |
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